PuraStat is a synthetic haemostatic material in the form of a prefilled syringe.
PuraStat is indicated for haemostasis in the following situations encountered during surgery, when haemostasis by ligation or standard means is insufficient or impractical:
- Bleeding from small blood vessels and oozing from capillaries of the parenchyma of solid organs
- Oozing from vascular anastomoses
- Bleeding from small vessels and oozing from capillaries of the GI tract
- Reduction of delayed bleeding following gastrointestinal endoscopic submucosal dissection (ESD) procedures in the colon
The matrix is formed from synthetic peptides which are composed of three naturally occurring amino acids in a sequence which is repeated 4 times. The peptides self-assemble to form a 3 dimensional matrix upon a change in pH2 caused by exposure to an ionic solution such as blood, peritoneal fluid or other bodily secretions.
PuraStat® mimics extra cellular matrix
The peptides in PuraStat® are synthetized in a specific sequence which provide the molecule with shape memory to enable them to self assemble into a scaffold which mimics human extra cellular matrix (ECM).
Based on results of scanning electron microscopy, the structure of PuraStat® self-assembling peptide hydrogel is understood to be a network of fibres with a diameter of around 10–20 nm and pores with a diameter of about 50–200 nm that resembles the mesh structure of natural collagen.
Applying PuraStat® is simple
PuraStat® is a haemostat existing of a nanofiber network structure that requires no preparation. This means it is ready to apply straight from packet to patient.
To apply PuraStat® is just as easy, simply deploy PuraStat® at the base of the lesion and wait, following the instructions below:
- Remove as much blood as possible from haemorrhagic site.
- Apply an adequate quantity of PuraStat to the haemorrhagic site.
- The nozzle should be as close as possible to the bleeding point.
- Do not disturb the self-assembled PuraStat gel until sufficient time has been allowed for haemostasis to occur.
- If necessary, repeat the application of PuraStat several times until haemostasis is achieved.
- After haemostasis is confirmed, excess PuraStat may be left in place.